ADVANCES IN THE DIAGNOSIS AND TREATMENT OF PANCREATIC DISEASES, AN ISSUE OF GASTROENTEROLOGY CLINICS, 36-2
Disorders of the pancreas have, in the past, been very frustrating because the diagnosis was often made late in the course of the disease and no significantly beneficial interventions were available. This situation is rapidly changing as new insights from multiple perspectives are integrated and focused on each step of this complex processes. Read More...
A genetic change in the DNA of individuals with pancreatic cancer from a large Seattle family (Family X) has been discovered. The genetic defect is in a gene previously mapped to chromosome 4 called "palladin". The details are available in the December 12, 2006 issue of PLoS Medicine. An overview of the findings is also available in the Winter 2006 issue of PEaRL. This discovery may open the door to a better understanding of pancreatic cancer, and hopefully ways to prevent or cure this terrible disease.
Click below for your FREE copy of the Pancreas Education and Research Letter (PEaRL). The PEARL is a patient oriented research letter to inform individuals and interested friends and families about ongoing research studies in hereditary panceatitis, acute pancreatitis, chronic pancreatitis, pancreatic cancer, important news related to pancreatic problems in cystic fibrosis, and the complications of pancreatic disease. PEARL will also highlight some of the major research and treatment centers that are leaders in pancreas research. The Editors of PEARL, Christina M. Chimera, MS and David C Whitcomb, MD PhD, hope that you enjoy PEARL and pass it on to interested friends.
Volume One: Number One
Volume One: Number Two
Volume One: Number Three
Volume Two: Number One
Volume Two: Number Three
Acute Pancreatitis-update: A new clinical practice review that was written by Dr Whitcomb on Acute Pancreatitis was published in the New England Journal of Medicine (May 18, 2006). The paper describes the standard evaluation, approach and treatment of mild and severe forms of this problem.
Pancreatic Cancer Collaborative Registry (PCCR)
PCCR is designed to unite centers with expertise in pancreatic cancer epidemiology, genetics, biology, early detection and patient care to facilitate rapid and uniform collection of critical information and biological samples to be used in developing prevention and treatment strategies against pancreatic cancer. The Pancreatic Adenocarcinoma Genetic and Environmental Risk (PAGER) study at the University of Pittsburgh is the most recent major academic center to join this effort. For more information, please visit their web site at http://pccr.unmc.edu/index.cfm.
Chronic Pancreatitis
New update on the cause of chronic pancreatitis is published in Nature Clinical Practice Gastroenterology & Hepatology. See the next to the last article in this free issue entitled Mechanisms of Disease: advances in understanding the mechanisms leading to chronic pancreatitis by David C Whitcomb MD PhD at http://www.nature.com/ncpgasthep/journal/v1/n1/index.html.
Early Diagnosis of Pancreatobiliary Cancers
Early diagnosis of pancreas and biliary cancers are critical for patient survival. The major problem facing clinicians is cytological interpretation of brushing from suspicious lesion during ERCP or EUS guided FNA. Genetic analysis of cells that are "indeterminate" for cancer may provide the critical answers needed in difficult cases. Genetic analysis of microdissected cells is now AVAILABLE. Preliminary reports have been published in Gastroenterology and Endoscopy News. Details are available through Redpath Integrated Pathology. (click on the icon near the top of the column to the right of this announcement)
PAGER: The Pancreatic Adenocarcinoma Gene-Environment Risk Study and Registry. The PAGER
programs are actively enrolling both patients, families, and people who may be
at risk for pancreatic cancer. The program is based at the Hillman Cancer
Center, which is the center of the University of Pittsburgh Medical Center
(UPMC) Cancer Centers. For more information, interest in participating, or for
other questions contact the staff toll free at 888-PITT-DNA. (The PAGER Registry is fully supportive of the PCCR - below)
Digestive Disease Week (DDW)
Los Angeles Convention Center
Los Angeles, CA
May 20-25, 2008
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