Super-trypsin in HP

1) Proenzymes

2) Low calcium

3) Compartmentalized

4) Trypsin inhibitor

5) Zymogen autolysis

6) Remote activation

7) _1- antitrypsin,

______ microglobulin

Nucleus

R.E.R.

Enterokinase

(normal trypsin trigger)

Lysosomes

Zymogens

(digestive

enzymes)

Trypsin

Golgi

Pancreatic Acinar Cell

Pancreas

Intestine

Premature

Activation

Normal

(autolysis)

Hereditary

Pancreatitis

(trypsin

activates

cascade)

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Notes:

Protective mechanism against premature trypsin activation. Since active trypsin has the potential of driving the pancreatic digestive enzyme activation cascade, a number of mechanism are employed to protect the pancreas and body from autodigestion. (1)