Pancreatic Diseases:Insights from Hereditary Pancreatitis

Written by

David C Whitcomb MD PhD

Department of Medicine, University of Pittsburgh

Educational Use ONLY

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The talk is based on the following work:

Whitcomb, DC, RA Preston, CE. Aston, MJ Sossenheimer, PS Barua, Y Zhang, A Wong-Chong, GJ White, PG. Wood, L Gates, C Ulrich, SP. Martin, JC Post and GD. Ehrlich, A Gene for Hereditary Pancreatitis Maps to an 19 cM Locus on Chromosome 7q35. Gastroenterol

Whitcomb, DC, MC Gorry, RA Preston, W Furey, MJ Sossenheimer, CD Ulrich, SP Martin, LK Gates, ST Amann, PP Toskes, R Liddle, K McGrath, G. Uomo, JC Post and GD Ehrlich. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Na

Lowenfels, AB, P. Maisonneuve, EP DiMagno, Y Elitsur, LK Gates, J Perrault, DC Whitcomb. Hereditary pancreatitis and the risk of pancreatic cancer. J.Nat. Cancer Inst. 89 (6):442-446, 1997

Sosssenheimer, MJ, C Aston, GD Ehrlich, L Gates, S Martin, C Ulrich, R Preston, DC Whitcomb. Clinical characteristics of hereditary pancreatitis in a large family based on high-risk haplotype. Am. J. Gastro. 92(7):1113-1116, 1997

Gorry, MC, D Gabbaizedeh, W Furey, LK Gates Jr, RA Preston, CE Aston, Y Zhang, C Ulrich, GD Ehrlich, and DC Whitcomb, Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis. Gastroenterology. 113:1063-1068,