Slide 5 of 13
Notes:
To find the chromosome region containing the affective gene, microsatellite markers from a number of chromosomes were sequentially tested for linkage with the disease gene. This led to the identification of the hereditary pancreatitis locus on chromosome
This figure illustrates the LOD score plot of microsatellite markers along chromosome 7. This is a statistic plot that proved that this region of DNA was inherited through the family tree with the hereditary pancreatitis trait.
The hereditary pancreatitis gene was on the same chromosome as the cystic fibrosis gene, and at the exact location of the T-cell receptor beta chain gene.
